Starting XI: Jonathan Klinsmann; Julián Araujo, Eriq Zavaleta, Nick DePuy, Raheem Edwards; Jonathan Pérez, Sacha Kjlestan ©, Daniel Aguirre, Efraín Álvarez; Dejan Joveljić, Kévin Cabral
Substitutions: Jonathan Bond; Séga Coulibaly, Kelvin Leerdam; Mark Delgado, Samuel Grandsir, Sacha Kljestan, Rayan Raveloson; Javier “Chicharito” Hernández
- Starting in goal is Jonathan Klinsmann, who makes his first appearance in 2022. Klinsmann has tallied two shutouts in seven career regular-season appearances for the Galaxy.
- Mexican National Team defender Julián Araujo makes his sixth start across all competition this season at right back. Araujo ranks tied for first on the team in chances created (11) in 2022.
- Making his LA Galaxy debut is Eriq Zavaleta, who has made 140 career MLS regular-season appearances (109 starts).
- Next to Zavaleta is Nick DePuy, who makes his sixth start across all competitions during the 2022 campaign.
- Playing at left back is Raheem Edwards, who ranks tied for first in MLS with five assists in seven games played (7 starts).
- Starting on the right side is Efraín Álvarez, who has tallied two goals in two career U.S. Open Cup appearances for the Galaxy.
- Sacha Kljestan makes his first start across all competitions in 2022. Kljestan has tallied five goals and three assists in 17 career U.S. Open Cup appearances.
- Daniel Aguirre starts alongside Kljestan for his first career start for the Galaxy. In 31 career appearances for Galaxy II, Aguirre has tallied three goals and four assists.
- Getting his first career start for the Galaxy is Mexican Youth International winger Jonathan Pérez. The 19-year-old has tallied five goals and six assists in 29 career appearances for USL Championship side LA Galaxy II.
- Starting up top is Kévin Cabral, who tallied five goals and two assists in 28 games played (24 starts) in his first season with the Galaxy during the 2021 MLS Regular Season.
- Playing next to Cabral is Dejan Joveljić, who tallied two goals and two assists in 14 games played (6 starts) last season with the Galaxy.