LA Galaxy Starting XI: GK Jonathan Bond; D Julián Araujo, D Séga Coulibaly, D Nick DePuy, D Raheem Edwards; M Gastón Brugman, M Mark Delgado, M Kévin Cabral, M Víctor Vázquez, M Samuel Grandsir, F Javier “Chicharito” Hernández ©
Substitutions: GK Jonathan Klinsmann; D Chase Gasper, D Kelvin Leerdam, D Eriq Zavaleta; M Daniel Aguirre, M Efraín Álvarez, M Douglas Costa, M Sacha Kljestan, F Dejan Joveljić
- Jonathan Bond, who has notched seven shutouts, makes his 24th appearance (24th start) during the 2022 MLS Regular Season. With his appearance against Vancouver, Bond will move past Jaime Penedo for sole possession of sixth place all-time in Galaxy regular-season appearances.
- Julián Araujo, who started and played 45 minutes in the MLS All-Star Game, makes his 96th career appearance across all competitions for the Galaxy.
- Séga Coulibaly makes his second consecutive start and his 19th appearance of the season in the match against Vancouver.
- Starting next to Coulibaly is Nick DePuy, who makes his first start in league play for the Galaxyz dating back to July 16.
- Playing on the left is Raheem Edwards, who leads the Galaxy with six assists in 21 appearances (19 starts) in his first season in LA.
- Gastón Brugman gets the start in midfield. Brugman has made three appearances (3 starts) since making his debut in a 2-0 win over Atlanta United FC on July 24.
- Mark Delgado, who has tallied two goals in 22 games played (21 starts) across all competitions for the Galaxy, gets the start in midfield.
- Starting on the right is Kévin Cabral, who has tallied eight goals and three assists in 54 career matches played (44 starts) across all competitions for the Galaxy.
- Víctor Vázquez, who makes his first start since July 13, makes his ninth start in league play during the 2022 campaign. Vázquez has tallied three assists in 17 games played in league play this season.
- Making his first start since July 13 is Samuel Grandsir, who has tallied one goal and three assists in 22 games played (12 starts) this year.
- Javier “Chicharito” Hernández, who captained the MLS All-Stars in their 2-1 win over Liga MX, gets the start for the Galaxy. Chicharito has tallied nine goals in 21 games played (20 starts) in league play this season.