Starting XI: GK Jonathan Bond; D Martín Cáceres, D Séga Coulibaly, D Derrick Williams, D Raheem Edwards; M Mark Delgado, M Gastón Brugman, M Riqui Puig, M Víctor Vázquez, F Kévin Cabral, F Javier “Chicharito” Hernández ©
Substitutions: GK Jonathan Klinsmann; D Julián Araujo, D Nick DePuy, D Chase Gasper; M Efraín Álvarez, M Douglas Costa, M Samuel Grandsir, M Sacha Kljestan, F Dejan Joveljić
- Jonathan Bond, who has notched seven shutouts, makes his 29th appearance (29th start) during the 2022 MLS Regular Season.
- Uruguayan National Team defender Martín Cáceres, who made his debut for the Galaxy in the 2-2 draw against Sporting KC on Sept. 4, makes his first start for the club against Nashville.
- Séga Coulibaly makes his seventh consecutive start and his 24th appearance of the season in the match against Kansas City.
- Playing next to Coulibaly is Derrick Williams, who makes his 24th appearance (22nd start) during the 2022 campaign.
- Starting at left back is Raheem Edwards, who has tallied six assists in 25 games played (22 starts) in league play this season.
- Gastón Brugman gets the start as the holding midfielder. Brugman has made eight appearances (8 starts) since making his debut in a 2-0 win over Atlanta United FC on July 24.
- Riqui Puig makes his fourth consecutive start dating back to Aug. 28. Puig has tallied one goal and two assists in his three starts for LA.
- Mark Delgado, who has tallied two goals and two assists in 23 appearances (23 starts) in his first season in LA, starts in midfield.
- Víctor Vázquez, who tallied his fourth assist of the season in the 2-2 draw against Sporting KC, starts for the 14th time this season for LA.
- Captaining the Galaxy is Javier “Chicharito” Hernández, who has recorded seven goals and two assists in his last six games played dating back to Aug. 6.
- Kévin Cabral starts alongside Chicharito. Cabral has tallied eight goals and five assists in 59 games played (48 starts) across all competitions for the Galaxy.